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Bipolar Disorder And Genes: The Latest Research

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By Chris Tepedino
Bipolar disorder, formerly known as manic-depression, is believed to have a strong genetic component and now researchers have discovered five major areas or gene regions that are implicated in the development of bipolar disorder within patients.
The study, titled “Genome-wide association study reveals two new risk loci for bipolar disorder,” was published in Nature Communications on March 11, 2014 and is detailed in a recent article on PsychCentral.com.
The team of researchers analyzed genetic information from 2,266 patients with bipolar disorder and 5,028 comparable people with the disorder. They merged this information with existing information from other individuals in various databases to analyze in total the genetic information from 9,747 patients and 14,278 non-patients.
Their analysis revealed five areas that were connected to bipolar disorder. Three of these five areas were already suspected to be connected to bipolar disorder. The two new areas were concentrated on chromosomes five and six.
In their study, the authors write, “Our finding provides new insights into the biological mechanisms involved in the development of bipolar disorder.”
Co-author Professor Marcella Rietschel says, “The investigation of the genetic foundations of bipolar disorder on this scale is unique worldwide to date.”
One of the new areas, called “ADCY2,” was of particular interest to researchers. This section of DNA oversees the production of an enzyme used in the conduction of signals into nerve cells.
Dr. Markus Nothen said, “This fits very well with observations that the signal transfer in certain regions of the brain is impaired in patients with bipolar disorder. Only when we know the biological foundations of this disease can we also identify starting points for new therapies.”
Genetics expert John Vincent said, “We’re all working toward establishing the ultimate set of genes associated with bipolar disorder, and then we can look at how they are involved in the functioning of neurons in the brain. We need to pool results with other studies to confirm the true associations, and this requires many tens of thousands of people.”

( view the original article here )

Batman TV Series ‘Gotham’ Is The Origin Story Of Bruce Wayne And Villains Before The Dark Knight

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The new Batman TV series Gotham has everyone speculating which direction the show will take the Dark Knight. One thing is for certain. This will be the most detailed version of the Batman origin story we have ever seen; diving into both the mythos of the city and the young Bruce Wayne.
In a related report by The Inquisitr, the Batman TV series Gotham will be heading to Netflix according to reports.

“The move, experts say, is part of an aggressive, comprehensive plan by Netflix to amass an enormous library of movies and television shows to become and remain the world’s dominant streaming service. There’s no word on the fiscal intricacies of the deal between Netflix and the company behind Gotham, but insiders say it’s a risky move at any cost. Gotham hasn’t even premiered yet, so no one really knows hows audiences will react to the show and in what numbers.”

Bruce Wayne kneels in his murdered parents’ blood.

The premise of the Batman TV series has some questioning the direction of the show. Bruce Wayne is just a kid while the city of Gotham will be explored mostly through the eyes of a young James Gordon; the man who will eventually become Gotham City’s police commissioner, the go to guy for Batman and the father of the future Batgirl aka Barbara Gordon.
Bruno Heller, executive producer, for the Batman TV series, explains how the story might differ from the comics.

“It’s not a whole new mythology. Mythology in the true sense of the word is precisely when so many stories are created that none of them can be consonant with each other. You name any mythological hero, and there are contradictions in the story… (Y)ou’ve reached the level of a genuine myth (when) many stories can be told. What we won’t do is break the kind of canonical iron truths of the Batman story. But issues of chronology and who was there when and how, we will play with. In a fun way, not in a disrespectful way or a sort of iconoclastic way.”

Batman TV Series 'Gotham' Is The Origin Story Of Bruce Wayne And Villains Before The Dark Knight

Much of the focus of the story will be how Gotham became the city that needs a Dark Knight in the first place and how the various Batman villains came to be.
The first focus will be on how Oswald Cobblepott becomes the Penguin by starting his career as a grunt for a new villain called Fish Mooney, who is a crime boss in Gotham. Cobblepott uses a split in the underworld between the Maroni family and the Falcone family to play both sides against each other. Interestingly enough, it will be the murder of Bruce Wayne’s parents that sets the foundation for Cobblepott becoming the Penguin in the long run.
Do you think the Batman TV series Gotham will be able to stand on its own without having the Dark Knight?
( view the original article here )

This is the how the Xbox One is finally going to compete with the PS4

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This is the how the Xbox One is finally going to compete with the PS4

In all the discussion regarding sales of the new game consoles from Sony and Microsoft, one important point is too often overlooked — the Xbox One is available in significantly fewer territories than the PlayStation 4. Sony had a huge jump on Microsoft in the international market, but by the end of September, the two consoles will finally be on a relatively level playing field.

Microsoft announced on the Xbox Wire on Tuesday that the Xbox One would be launching in 29 new territories before the end of the month. Here’s a complete list of dates:

9/2: Chile and Colombia
9/4: Japan
9/5: Belgium, Czech Republic, Denmark, Finland, Greece, Hungary, Netherlands, Norway, Poland, Portugal, Saudi Arabia, Slovakia, Sweden, Switzerland, Turkey, United Arab Emirates
9/15: Israel
9/23: Hong Kong, India, Korea, Singapore, South Africa, Taiwan
9/23: China
9/26: Russia

For Xbox fans, the explanation for the console’s lack of runaway success always came down to one issue: availability. You simply couldn’t get the Xbox in some of the most important video game markets on the planet, most notably Japan, but that won’t be true in less than 30 days. It’s going to take time for Microsoft to make an impact in countries where the PS4 has already taken over the living room, but at least we’ve finally got a fair fight.

( view the original article here )

WWE: CM Punk Wanted Wrestling, Not Vince McMahon's 'Sports Entertainment'

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When CM Punk informed Vince McMahon he was leaving after Royal Rumble, his attitude regarding his profession was apparently one of the driving forces regarding the reason he turned his back upon the WWE.

Within a related report by The Inquisitr, stories claim that AJ Lee might quit the WWE to totally focus on having children. Mick Foley believes should that CM Punk’s WWE return does occur, then it would have to be under circumstances where he will not be forced to make himself look bad or turn into a jobber for Vince McMahon ordinarily to promote the rise of another WWE superstar.

It may be stated that Randy Orton is dealing with identical conundrum within their own career since his recent feud with Roman Reigns seems designed only to increase the Samoan Superman till the point that Brock Lesnar Vs. Roman Reigns at WrestleMania 31 is plausible.

A little amount of how CM Punk views the WWE and of course the industry overall was revealed when Hornswoggle discussed how Phil Brooks influenced him personally.

“When considering wrestling, I use that word versus sports entertainment, I use wrestling on a regular basis, due the the fact i am a wrestling fanatic,” mentioned Hornswoggle. “CM Punk once mentioned this could be still wrestling to really us, this isn’t sports entertainment to us, because we was raised on wrestling.”

Hornswoggle also gave us insight into the personal character of Vince, stating, “He is that this billionaire, but still just loves this industry.” Without a doubt, Vince McMahon’s net-worth already has grabbed a dive lately since his money is largely involved into WWE stock, making him “only” a multi-millionaire, but it’s always been noted that Vince is first and always geared toward whatever is “good with regards to business enterprise.” This attitude reveals itself in terms of the cost cutting measures has cheapened the general quality of one's shows and the way the WWE layoffs continue using this week. Vince also seems to consider other major sports entertainment like the NFL to be their main competition, not guaranteed to be other wrestling outfits just like TNA, Ring of Honor, or New Japan Pro Wrestling.

But CM Punk and AJ Lee are only attempting to put everything stress behind them, in most cases. Lee is facing Paige again in the course of the night Of Champions 2014, but otherwise they're just enjoying time being a partners. Depending on their Twitter accounts, it appears like they’re just catching up on enjoying dvds. They’ve also been discussing the events of one's Walking Dead.

AJ Lee has as well been retweeting photos of her fans wearing her clothing as well as other merchandise.

Otherwise, if Phil is organizing a CM Punk WWE return back, he certainly isn’t telling any person. Punk is looking at himself simply as his given name, Phil Brooks, when he does make the rare public appearance.

What would you say concerning the differing viewpoints of CM Punk and Vince McMahon?

5 Seconds of Summer Bass Player Cops to Flashing Dong around The Web

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5 Seconds of Summer's Bass Player

5 Seconds of Summer's bass player now has a viral penis -- which isn't as bad since it sounds -- but yes ... his junk's being passed all around the Internet after he flashed it on Snapchat.

Calum Hood learned a tough lesson (pun intended, we have seen the video) when he sent the revealing video to somebody who then reposted it as a Vine to share with the world to see. So, now ya know, Calum -- famous naked penises Keep getting leaked.

Even though you never see 18-year-old Hood's face within the video ... he took the brutally honest step of admitting it was him by tweeting ... "I'm still just a teenage kid learning from mistakes ;)"

So, he's young, dumb, and ...

Sexy yoga coach becomes a huge Internet hit in China

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Named as “the most beautiful yoga coach in Asia” and “the goddess of yoga”, Muqi Miya has recently become an ×Internet sensation on China’s social media sites, boasting a sea of devoted fans. No surprises here.
A real post-90’s generation baby, ×Miya started out as a promoter of the ×Yoga movement and later founder of the brand “Miya Life”, before she began modeling and acting.

Born in South China’s Yunnan Province, she began practicing Yoga from 17 years old, and said that it inspired her and gave her a positive attitude towards life.
With a sexy figure and sweet smile, as well as her attitude towards a healthy and fit life, she has become a role model for many young girls.

With many people in China pursuing healthier lifestyles today, many are seeking new ways, such as yoga and meditation to improve their lives.

( source )

First Look: AVENGERS #35

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By Tony 'G-Man' Guerrero

This September, it all comes crashing down as Earth’s Mightest Heroes face judgment day – and today, Marvel is proud to present your first look at the oversized AVENGERS #35! The star-studded creative team of Jonathan Hickman, Jim Cheung, Dustin Weaver, Nick Bradshaw and Paco Media fast-forward 8 months, to the battle worn Marvel Universe of tomorrow – and the bleak future facing our heroes. Peer into May 2015, heroes and villains of the Marvel Universe stand at the precipice, and utter decimation looms.

Incursions by parallel Earths from other dimensions have increased in number! To save both universes, one Earth must be destroyed each time! Until now the Illuminati have dealt with this problem in secret. But 8 months from now, the secret is out! The Avengers and the Illuminati are willing to go to war over what must be done – but how could this all have happened?

“In addition to setting the table for the astonishing climax of Jonathan Hickman’s run, we’ll also be providing a glimpse into the immediate future of many of our characters, and what changes await them over the next 8 months of publishing,” says Executive Editor Tom Brevoort in an interview with Marvel.com. “This isn’t some maybe-future, this is the real deal, what’s awaiting the Marvel Universe in the coming year.”

As this epic, oversized issue jumps forward into the future, what has become of Earth’s Mightiest Heroes? With the war between the Avengers and the Illuminati at its peak, who will be left to fend off the Final Incursion? And what will happen if they fail? The clock is ticking and your questions will be answered this September in AVENGERS #35!